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5-a]pyridin-3-yl]propan-1-one
Eiermann G
It effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages without siginificanty inhibition on cell viability
Hep3B and HepG2 cells with IC50 values below 1 μM
safe and effective HIV-1 attachment inhibitor
VAL-083 - CAS# 23261-20-3 inone I 5-a]pyridin-3-yl]propan-1-oneVAL 083 is a bi functional alkylating agent, with potential antineoplastic activity. Upon administration, VAL 083 crosses the blood brain barrier (BBB) and appears to be selective for tumor cells. This agent alkylates and crosslinks DNA which ultimately leads to a reduction in cancer cell proliferation. In addition, VAL 083 does not show cross resistance to other conventional chemotherapeutic agents and has a long half life in the brain. Product
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